Review: La Roche-Posay – Toleriane Ultra Dermallergo Soothing Serum (and what is Neurosensine?)

Where to purchase: The La Roche Posay Website: LINK / Look Fantastic: LINK / Feel Unique: LINK / Boots: LINK

Price: £28

Volume: 20ml

Made in: France

What is it?: A Serum that eases Sensitive + Sensitised Skin.

What does it do?: A Neurosensine serum that hydrates the skin + restores the skin’s barrier + helps reduce skin irritation / sensitivity e.g tightness, dryness and itchiness.

Supposedly Good for: Sensitive, reactive skin prone to dryness, tightness and, itchiness + Allergy-prone skin.

What I think: This isn’t an emollient product so I don’t think Dry Skins would like it as much as Combination and especially: Dehydrated skins would.


Vegan?: No

Cruelty Free?: La Roche Posay sell in China which may request animal testing.

How long does it last after opening?: 12 Months

Packaging: Glass bottle with a dropper. The dropper is thick.

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Directions: Apply this serum in the AM and PM on the face and neck. Note: You can store this in the fridge 30 minutes before applying to provide a cooling effect on the skin.

How I use it: I apply this if and when the skin is sensitised, after toning and solutions but before a cream/moisturiser. I don’t reach for it unless my skin is sensitised as this doesn’t contain things like peptides and niacinamide to further benefit my skin. But I definitely reach for this when everything else stings the skin.

They Key Ingredient: 0.1% Neurosensine, or: ”Acetyl Dipeptide-1 Cetyl Ester”: This is a cell-communicating ingredient. It is made up of Tyrosine and Arginine (soothing peptides) that together, causes the skin’s nerve cells to release met-enkephalin which is an opioid (i.e. it’s a pain-relieving/soothing messenger molecule). Therefore Neurosensine signals the cells to relax and therefore reduces the feeling of irritation sensitised skins may experience. That’s why it makes it a good and effective ingredient to include in a serum aimed at sensitive and irritated skins.


Other Key Ingredients: Glycerin + Hyaluronic Acid + Betaine (Hydrating + Moisturising).

NOTE: La Roche-Posay’s famed Thermal Spring Water is also included as it also helps soothe the skin and restore the skin’s barrier (Thermal Spring Water does help soothe the skin).

Full Ingredients: Aqua / Water, Dipropylene Glycol, Glycerin, Betaine, Propanediol, Pentylene Glycol, Peg-8, Polysorbate 20, Peg/Ppg/Polybutylene Glycol-8/5/3 Glycerin, Sodium Hyaluronate, Ammonium Polyacryloyldimethyl Taurate, Hydroxyacetophenone, Caprylyl Glycol, Citric Acid, Acetyl Dipeptide-1 Cetyl Ester.

NOTE: The Incidecoder have a full ingredient breakdown HERE

Texture: The company state that this has a light and refreshing texture – I would agree. However this is still a relatively thick serum (it’s gloopy like most of La Roche-Posay and The Ordinary’s Serums). It doesn’t feel cooling, but it definitely feels soothing. It’s easy to spread this along the skin and dries down relatively quickly (see pictures and swatch video below). This doesn’t feel oily or greasy but due to its gel nature – I recommend applying a cream on top to reduce any chance of stickiness or balling up. Applying this onto sensitised skin – this does not sting which is great.

As you can see, although gloopy this liquid still runs down the hand.


This definitely feels hydrating and non-reactive.

Does this Sting if the Skin has been Irritated / Sensitised by Shaving/Heavy Retinol Use?: No! In fact, it feels cooling and calming when in contact with the skin.

Summer or Winter?: Can be used all year round as it is a a gel-like serum. Oily Skins may prefer it in the winter, depending on what else is layered.

Layerable?: It seems to be fine, but don’t layer on or with facial oils (might ball up).


Video Swatch:

Fragrance?: No added Fragrance or EO.

Good Under Makeup?: It should be fine (just don’t use too much or an oil-based foundation).

How long have I been using this?: 2 Months

Will I use until Completion?: Yes!

How Long will that take?: 3 Months

The Effect?: Soothed and Hydrated Skin. No stinging, itching or burning. I know La Roche Posay say this is really great for tight and dry skin – I would say of course this hydrates the skin, but I still wouldn’t recommend it to dry skins as much as Combo skins because this doesn’t have that emulsion texture or fatty ingredients that Dry Skins crave. I think it would have been better worded if they said ”Dehydrated Skin”.

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What I like:

  • Fragrance + EO Free
  • Great for when the Skin is Sensitised
  • Genuinely Calms down / Soothes the skin
  • Hydrating
  • As this is a serum, it’s lightweight

What I don’t like:

  • Potential to ball up (can’t use more oil-like products on top)
  • Can get a bit gloopy/messy especially with this type of packaging + dropper (this is a thicker gel serum)

Overall Rating and Conclusion: 4/5 – A serum that does the job! I’m so grateful I have another product (there aren’t many on my list unfortunately!) that I can use if and when the skin is sensitised/irritated. This is a product I only reach for if the skin is sensitised; but it does that job very well. I will say the texture is quite thick/gloopy for a gel (like most La Roche-Posay and The Ordinary serums are), so I took a point off, but it does mean that it’s hydrating! I feel like if Cica was added, it would have made this product even more special.

Would I repurchase?: Yes!

Dupe?: The Geek & Gorgeous Stress Less Serum LINK (My Review HERE).

My Skin Type: I am acne prone and have slightly dehydrated combo skin. My skin is usually tight where the cheeks and eye area is and the outer parts of my face. My T zone is oily. My skin isn’t a fan of thick/heavy formulas so I opt for lightweight formulas to prevent it from clogging up. My skin doesn’t like essential oils either and I try to avoid fragrance when I can.

Disclaimer: I am a skincare enthusiast and not a skin expert. I am not qualified to give out dermatological advice. This type of advice should only be given by a medical practitioner. Upon trying / using any of the reviewed products on the blog, please follow the manufacturer’s instructions and warnings and please seek medical advice if needed.

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4 thoughts on “Review: La Roche-Posay – Toleriane Ultra Dermallergo Soothing Serum (and what is Neurosensine?)

  1. I got this serum a while ago and I like it! It’s not heavy, sinks in well, and genuinely feels like it hydrates the skin. I agree that it is not the most ideal serum for particularly dry skin, but good for combo skin! Especially if you top it with a good moisturizer – It works really well.
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